Background. Public health policies such as tobacco control, air pollution reduction and hazardous waste remediation may have reduced cadmium exposure among US adults. However, trends in urine cadmium, a marker of cumulative cadmium exposure have not been evaluated.
Objectives. To estimate trends in urine cadmium concentrations in US adults from 1988 to 2008 using data from the National Health and Nutrition Examination Surveys. We also evaluated the impact of changes in the distribution of available cadmium determinants (age, sex, race, education, body mass index, smoking and occupation) at the population level to explain cadmium trends.
Methods. The study population included 19,759 adults ≥20 years old with measures of urine cadmium and cadmium determinants.
Results. Age-adjusted geometric means of urine cadmium concentrations were 0.36, 0.35, 0.27, 0.27, 0.28, 0.25 and 0.26 μg/g creatinine in 1988-91, 1991-94, 1999-2000, 2001-02, 2003-04, 2005-06 and 2007-08, respectively. The age, sex and race/ethnicity-adjusted percent reduction in urine cadmium geometric means comparing 1999-2002 and 2003-08 to 1988-94 were 27.8 % (95% confidence interval 22.3, 32.9%) and 34.3% (29.9, 38.4%), respectively (p-trend <0.001), with reductions in all participant subgroups investigated. In never smokers, reductions in serum cotinine accounted for 15.6% of the observed reduction. In ever smokers, changes in smoking cessation, and cumulative and recent dose accounted for 17.1% of the observed reduction.
Conclusions. Urine cadmium concentrations decreased markedly between 1988 and 2008. Declining smoking rates and changes in exposure to tobacco smoke may have played an important role in the decline of urine cadmium concentrations, benefitting both smokers and non-smokers. Cadmium has been associated to several health outcomes in NHANES 1999-2008. Consequently, despite the observed decline, further reduction in cadmium exposure is needed.